The story follows three convicts—Ulysses Everett McGill (Clooney), Pete Hogwallop (Turturro), and Delmar O’Donnell (Nelson)—who escape from a Mississippi chain gang in search of a hidden treasure that Everett claims to have buried. Their journey is filled with bizarre encounters, including a blind prophet, a seductive trio of sirens, a sinister one-eyed Bible salesman (a nod to the Cyclops), and a corrupt politician.

Along the way, the trio accidentally becomes famous as “The Soggy Bottom Boys” after recording a hit folk song, I Am a Man of Constant Sorrow. Unbeknownst to them, their music spreads across the South, turning them into folk heroes. However, their real goal is to reach Everett’s estranged wife, Penny (Holly Hunter), and win her back before she remarries.

As they evade the relentless sheriff, Cooley, the film’s themes of fate, redemption, and the power of music unfold. The climax sees the trio narrowly escape execution when a sudden flood—reminiscent of divine intervention—washes away their captors. Everett finally reunites with Penny, but she insists he must retrieve her wedding ring, sending him on yet another quest.

With its witty dialogue, rich cinematography, and memorable performances, O Brother, Where Art Thou? is a unique blend of folklore and historical satire. Its Grammy-winning soundtrack helped revive interest in American folk music, making it a beloved modern classic.